Key clinical point: Concerns may be unfounded about risks of earlier-onset cardiovascular disease in men with hemophilia A.
Major finding: Prevalence rates of diabetes (P = .0108) and hyperlipidemia (P = .0001) were higher in the control group, compared with patients with hemophilia A.
Study details: A retrospective chart review involving 74 men with hemophilia A and 222 men without the condition, matched by study year, payer type, race, and age.
Disclosures: The study was funded by Bayer. Three authors were employed by Bayer when the study was conducted. Other authors reported employment by Xcenda and the Henry Ford Health System and research funding from Xcenda.
Humphries TJ et al. Adv Med Sci. 2018;63(2):329-33.
This Week's Must Reads
Intensity modulated radiation therapy may be preferable in children with extremity nonrhabdomyosarcoma soft-tissue sarcomas, Source: Rao A et al. Intl J Rad Oncology*Biology*Physics; Jan. 2019, 38-44. https://doi.org/10.1016/j.ijrobp.2018.09.005
Outcomes better in TNBC with adjuvant chemotherapy within 30 days of surgery, Morante Z et al., SABCS 2018 Abstract GS2-05
TAO: Nonwhite ethnicity, limb infection predict poor prognosis, Le Joncour A et al. Arthritis Rheumatol. 2018;70(Suppl 10): Abstract 1885
Thrombolysis for acute ischemic stroke safe in GI malignancy, Inohara T et al. Circulation. 2018 Nov 6;138[suppl 1], Abstract A12291
Ten years of anastrozole boosts disease-free survival, Ohtani S et al. SABCS 2018, Abstract GS3-04
Must Reads in Bleeding Disorders
FDA draft guidance on platelet safety, FDA Draft Guidance, December 2018
HemoTypeSC offers rapid sickle cell detection, Serrao E et al. ASH 2018, Abstract LBA-3
Impact of RBC transfusion limits, Roubinian NH et al. Ann Intern Med. 2018 Dec 18. doi: 10.7326/M17-3253
Early results for novel hemophilia A infusion, Chowdary P et al. ASH 2018, Abstract 489
Diagnostic challenges in hemophilia A, Patil R et al. Thromb Res. 2018 Dec;172:29-35