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Newly identified genetic changes contribute to transformation of follicular lymphoma

Key clinical point: Newly discovered genetic changes in the transformation from follicular lymphoma to B-lymphoblastic leukemia/lymphoma may lead to novel therapeutic approaches.

Major finding: Comparative whole exome sequencing indicated that the FL specimen contained 116 mutations – 11 of which were shared solely with B-ALL/LBL – and the B-ALL/LBL specimen contained 575 unique mutations.

Study details: A case study of a 36-year-old man with follicular lymphoma that transformed into B-lymphoblastic leukemia/lymphoma about 1 year after initial diagnosis.

Disclosures: The study was funded by a grant from the National Institutes of Health, the Abramson Cancer Center Translational Center in Lymphoma, the Daniel B. Allanoff Foundation, and a Hematopathology Divisional Training grant.

Citation:

Belman JP et al. Cold Spring Harb Mol Case Stud. 2019 Nov 27. doi: 10.1101/mcs.a004614.