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CNS-directed Therapy Appears More Effective for synDLBCL

Key clinical point: Patients who have diffuse large B-cell lymphoma with synchronous CNS and systemic disease (synDLBCL) have better outcomes when they receive CNS-directed therapy.

Major finding: The 2-year overall survival rate was 54% in patients who received CNS-intensive therapy and 44% in those who received CNS-conservative therapy (P = .037).

Study details: A retrospective study of 80 patients with synDLBCL.

Disclosures: There was no formal funding for the study. and the researchers did not provide financial disclosures.


Wight JC et al. Br J Haematol. 2019 Jun 24. doi: 10.1111/bjh.16064.