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Oxidatative stress-related genetic variant tied to stroke risk in sickle cell patients

Key clinical point: SOD2 Val16Ala polymorphism may represent a simple and inexpensive alternative for identifying sickle cell patients at risk of stroke.

Major finding: SOD2 Val16Ala polymorphism was independently associated with an increased risk of stroke (odds ratio, 1.98; P = .009).

Study details: A total of 499 unrelated adult patients with sickle cell disease were genotyped.

Disclosures: The authors reported that they had no competing financial interests.


Domingos IF et al. J Neurol Sci. 2020 Apr 16. doi: org/10.1016/j.jns.2020.116839.