Clinical Edge

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In Older Patients With Immune-Mediated TTP, Atypical Features May Delay Diagnosis

Key clinical point: Older patients with immune thrombotic thrombocytopenic purpura (iTTP) more often have an atypical neurological presentation, which could result in a delayed diagnosis.

Major finding: Time from hospital admission to diagnosis was 3 days for those older patients, versus just 1 day for patient under 60 years of age (P = .0001).

Study details: An analysis of 411 iTTP patients entered into a French registry between 2000 and 2016.

Disclosures: The study was partly funded by a grant from the French Ministry of Health. Study authors reported disclosures related to Alexion, Ablynx (now part of Sanofi), Shire, and Octapharma.


Prevel R et al. Blood. 2019 Sep 17. doi: 10.1182/blood.2019000748.