Clinical Edge

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Genetic variants may predict stroke in some adult SCD populations

Key clinical point: Oxidative stress–related genetic variants may identify adult sickle cell disease patients at risk of stroke.

Major finding: SOD2 Val16Ala polymorphism was independently associated with the risk of stroke (odds ratio: 1.98; P = .009).

Study details: A total of 499 unrelated patients with sickle cell anemia aged > 18 years were genotyped and reviewed for stroke incidence.

Disclosures: The authors reported that they had no competing financial interests.


Domingos IF et al. J Neurologic Sciences. 2020;