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Vadastuximab talirine improves AML remission rates

Fathi AT et al. Blood. 2018 Jul 25. doi: 10.1182/blood-2018-03-841171.

Key clinical point: For older patients with CD-33 positive AML, vadastuximab talirine plus a hypomethylating agent improves remission rates.

Major finding: The composite remission rate in patients treated with vadastuximab talirine and HMA therapy was 70%, compared with 17.8%-27.8% for patients treated with HMA therapy alone historically.

Study details: A prospective, phase 1 trial involving 53 elderly patients with CD33-positive AML at 14 treatment centers.

Disclosures: Seattle Genetics provided study funding and author compensation.

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Citation:

Fathi AT et al. Blood. 2018 Jul 25. doi: 10.1182/blood-2018-03-841171.

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