Key clinical point: A treosulfan-based conditioning regimen could become a standard prior to allogeneic transplant in elderly or comorbid patients with acute myeloid leukemia (AML) or myelodysplastic syndromes (MDS).
Major finding: Event-free survival at 2 years was 65.7% and 51.2%, respectively, for the treosulfan- and busulfan-based conditioning regimens (P = .0000001).
Study details: Final analysis of the randomized phase 3 MC-FludT.14/L study, including 551 patients with AML or MDS.
Disclosures: Dr. Beelen reported honoraria, travel support, and trial documentation support provided by medac GmbH, which sponsored the trial.
Beelen DW et al. TCT 2019, Abstract 4.
Must Reads in AML
IDH-mutated AML: First-line IDH inhibitors, chemo may up remission, Stein EM et al. ASH 2018, Abstract 560
Rapid genomic results possible, Beat AML trial suggests, Burd A et al. ASH 2018, Abstract 559
Phase 2 results for combo therapy in relapsed AML, Daver N et al. Cancer Discov. 2018 Nov 8. doi: 10.1158/2159-8290.CD-18-0774