Key clinical point: The AP-1 transcription factor family plays an important role in acute myeloid leukemia.
Major finding: The AP-1 factor family gene regulatory network was of high regulatory relevance in multiple subtypes of AML with defined mutations.
Study details: Analysis of normal CD34+ cells and cells from AML subjects.
Disclosures: Funding came from Bloodwise and Cancer Research UK, among other sources. The researchers reported having no competing financial interests.
Assi SA et al. Nat Genet. 2018 Nov 12. doi: 10.1038/s41588-018-0270-1.