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Polygenic risk score may predict VTE in adolescents, but not adults, with ALL

Key clinical point: Adolescents with acute lymphoblastic leukemia appear to be at increased genetic risk of thromboembolism.

Major finding: The best fit polygenic risk score, including 16,144 single-nucleotide polymorphisms, was associated with venous thromboembolism in adolescents with acute lymphoblastic leukemia at a hazard ratio of 1.76 (95% confidence interval, 1.23-2.52; P = .02).

Study details: The researchers assessed the prospectively registered venous thromboembolism events and collected germline DNA in patients aged 1-45.9 years in the Nordic Society of Pediatric Hematology and Oncology ALL2008 study.

Disclosures: The study was supported by research grant from the South-Eastern Norway Regional Health Authority. The authors reported that they had no conflicts of interest.


Jarvis KB et al. Thromb Res. 2020 Aug 11. doi: 10.1016/j.thromres.2020.08.015.