Clinical Edge

Summaries of Must-Read Clinical Literature, Guidelines, and FDA Actions

Orthopedic problems in children can be the first indication of acute lymphoblastic leukemia

Key clinical point: Orthopedic manifestations in children may be the primary presentation of ALL and should be cause for suspicion.

Major finding: A total of 22 patients (8.8%) presented primarily to the orthopedic department.

Study details: A retrospective study of 250 consecutive ALL cases evaluated to identify cases with musculoskeletal manifestations.

Disclosures: The authors reported that there was no outside funding source and that they had no conflicts.


Raj BK A et al. Journal of Orthopaedics. 2020;22:326-30.