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Exercise intolerance linked to neurocognitive dysfunction in ALL

Key clinical point: Exercise intolerance was associated with worse neurocognitive function in adult survivors of pediatric acute lymphoblastic leukemia.

Major finding: Acute lymphoblastic leukemia survivors had lower mean relative peak volume of oxygen scores and worse performance on several neurocognitive measures, compared with controls (all P less than .001).

Study details: A cross-sectional cohort study of 341 adult survivors of pediatric acute lymphoblastic leukemia and 288 healthy controls.

Disclosures: The study was supported by the National Institutes of Health and the American Lebanese Syrian Associated Charities. The researchers did not report conflicts of interest.


Phillips NS et al. Cancer. 2019 Oct 21. doi: 10.1002/cncr.32510.