Key clinical point: Cerebrospinal fluid metabolites were significantly associated with fatigue in children with acute lymphoblastic leukemia.
Major finding: The abundance of gamma-glutamylglutamine, dimethylglycine, and asparagine in postinduction cerebrospinal fluid samples was significantly associated with fatigue.
Study details: Pediatric acute lymphoblastic leukemia patients were divided into discovery (n = 86) and replication (n = 85) cohorts, and cerebrospinal fluid samples were taken and assessed.
Disclosures: The study was sponsored by the National Cancer Institute and several nonprofit organizations. The authors reported that they had no conflicts of interest.
Brown AL et al. J Pain Symptom Manage. 2020 Sep 1. doi: 10.1016/j.jpainsymman.2020.08.030.