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CSF metabolomic profile linked to cancer-related fatigue in children with ALL

Key clinical point: Cerebrospinal fluid metabolites were significantly associated with fatigue in children with acute lymphoblastic leukemia.

Major finding: The abundance of gamma-glutamylglutamine, dimethylglycine, and asparagine in postinduction cerebrospinal fluid samples was significantly associated with fatigue.

Study details: Pediatric acute lymphoblastic leukemia patients were divided into discovery (n = 86) and replication (n = 85) cohorts, and cerebrospinal fluid samples were taken and assessed.

Disclosures: The study was sponsored by the National Cancer Institute and several nonprofit organizations. The authors reported that they had no conflicts of interest.


Brown AL et al. J Pain Symptom Manage. 2020 Sep 1. doi: 10.1016/j.jpainsymman.2020.08.030.