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Triggers of Hypercalcemia in Patients with NHL

Clin Lymphoma Myeloma Leuk; ePub 2017 Dec 29; Shallis, et al

Calcitriol and parathyroid-related protein do not appear to play a role in hypercalcemia that develops in patients with non-Hodgkin lymphoma (NHL), according to a study involving 54 individuals. Investigators looked at 1) factors that led to hypercalcemia in participants with NHL and at least 1 hypercalcemia episode and 2) overall survival. Among the results:

  • 57% of patients had diffuse large B-cell lymphoma; 7 in every 10 of them had the non-germinal center subtype.
  • 61% of patients whose serum parathyroid-related protein and calcitriol levels were properly collected did not show elevations of either.
  • The degree of calcitriol elevation was found to correlate with worse progression free but not overall survival.

The authors noted that calcitriol may be a marker of high-grade lymphoma or transformation to it.


Shallis R, Rome R, Reagan J. Mechanisms of hypercalcemia in non-Hodgkin lymphoma and associated outcomes: A retrospective review. [Published online ahead of print December 29, 2017]. Clin Lymphoma Myeloma Leuk. doi:10.1016/j.clml.2017.12.006.