Clinical Edge

Summaries of Must-Read Clinical Literature, Guidelines, and FDA Actions

5F9 plus rituximab looks durable in NHL

Advani R et al. N Engl J Med. 2018;379:1711-21

Key clinical point: Hu5F9-G4 plus rituximab was safe and produced durable complete responses in patients with relapsed or refractory non-Hodgkin lymphoma.

Major finding: Rates of overall and complete responses were 50% and 36%, respectively, with most responses ongoing at the time of data cutoff.

Study details: A phase 1b study of 22 patients, including 15 with diffuse large B-cell lymphoma and 7 with follicular lymphoma.

Disclosures: The study was supported by Forty Seven and the Leukemia & Lymphoma Society. Study authors reported disclosures related to Forty Seven, Bristol-Myers Squibb, Pharmacyclics, Seattle Genetics, and Roche/Genentech, among others.

Read the articles here.


Advani R et al. N Engl J Med. 2018;379:1711-21.