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Risk of Advanced Liver Disease in Hispanics

Clin Gastroenterol Hepatol; ePub 2018 Dec 7; Turner, et al

The risk of advanced liver disease was far greater in hepatitis C virus (HCV)-infected Hispanics with obesity and diabetes than in other racial or ethnic groups, a new study found. Researchers analyzed data from persons with 748 HCV infection (22% Hispanic, 53% non-Hispanic black, and 26% non-Hispanic white; 23% with advanced liver disease), born from 1945 through 1965. A propensity score-matched analysis was performed to determine whether metabolic risk factors contribute to this disparity. They found:

  • The adjusted odds ratios (AORs) of advanced liver disease, including fibrosis and cirrhosis, for Hispanics who were obese (BMI ≥30) with a diagnosis of diabetes were 7.89 vs non-Hispanic black patients and 12.49 vs non-Hispanic white patients, respectively.
  • The AORs BMI <25 with or without diabetes, were > 2-fold greater for Hispanic than non-Hispanic black or non-Hispanic white patients.


Turner BJ, Wang C-P, Melhado TV, Bobadilla R, Jain MK, Singal AG. Significant increase in risk of fibrosis or cirrhosis at time of HCV diagnosis for Hispanics with diabetes and obesity compared with other ethnic groups. [Published online ahead of print December 7, 2018]. Clin Gastroenterol Hepatol. doi:10.1016/j.cgh.2018.11.059.