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Summaries of Must-Read Clinical Literature, Guidelines, and FDA Actions

Liver Stiffness Improves After HCV Antiviral Tx

Clin Gastroenterol Hepatol; 2018 Jan; Singh, et al

Eliminating hepatitis C virus (HCV) infection reduces liver stiffness, according to a recent systematic review of 24 studies. Among the details:

  • Eradicating HCV, as evidenced by a sustained viral response to therapy, has been linked to a decline in liver stiffness, which results from hepatic inflammation and fibrosis.
  • Investigators looked at studies in which liver stiffness was measured using vibration-controlled transient elastrogprahy (VCTE) to assess the effects of direct-acting antivirals and interferon-based treatment.
  • Patients who achieved a sustained viral response (SVR) to treatment experienced a median decrease in liver stiffness of 28.2% while patients who didn’t have a SVR saw no significant improvement in stiffness.
  • Improvements in liver stiffness were greater among patients on direct-acting antivirals, when compared to those on interferon-based therapy.


Singh S, Facciorussoa A, Loomba R, et al. Magnitude and kinetics of decrease in liver stiffness after antiviral therapy in patients with chronic hepatitis C: A systematic review and meta-analysis. Clin Gastroenterol Hepatol. 2018;16:27-38.e4. doi:10.1016/j.cgh.2017.04.038.

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