Key clinical point: A high-calorie diet may cause earlier onset of more severe Wilson disease.
Major finding: Disease onset occurred 20 days sooner when Wilson disease rats were fed a high-calorie diet, compared with a normal diet; a major difference, considering the median 106-day lifespan of Wilson disease rats fed a normal diet.
Study details: A rodent study using control (Atp7b+/–) and Wilson disease (Atp7b–/–) rats.
Disclosures: The study was funded by Deutsche Forschungsgemeinschaft and the WiFoMed Society. The investigators disclosed no conflicts of interest.
Einer et al. Cell Mol Gastroenterol Hepatol. 2019 Jan 11. doi: 10.1016/j.jcmgh.2018.12.005.