Clinical Edge

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High-Calorie Diet May Worsen Wilson Disease

Key clinical point: A high-calorie diet may cause earlier onset of more severe Wilson disease.

Major finding: Disease onset occurred 20 days sooner when Wilson disease rats were fed a high-calorie diet, compared with a normal diet; a major difference, considering the median 106-day lifespan of Wilson disease rats fed a normal diet.

Study details: A rodent study using control (Atp7b+/–) and Wilson disease (Atp7b–/–) rats.

Disclosures: The study was funded by Deutsche Forschungsgemeinschaft and the WiFoMed Society. The investigators disclosed no conflicts of interest.


Einer et al. Cell Mol Gastroenterol Hepatol. 2019 Jan 11. doi: 10.1016/j.jcmgh.2018.12.005.