Obesity and weight gain since early adulthood are associated with lower risk of microscopic colitis, a new study found. In a prospective cohort study, researchers collected data from 192,101 women enrolled in the Nurses’ Health Study (NHS) or NHSII and examined the association between obesity and risk of microscopic colitis. They found:
- There were 244 confirmed cases of microscopic colitis during 4,223,868 persons-years of follow up among participants in NHS and NHSII.
- Higher body mass index (BMI) was inversely associated with risk of microscopic colitis.
- Weight gain since early adulthood (age 18 years) was also inversely associated with risk of microscopic colitis.
- The adjusted hazard ratio for each 10 kg weight gain since early adulthood was 0.85.
- The associations were not modified by age, cohort, physical activity, or smoking status.
Liu P-H, Burke KE, Ananthakrishnan AN, et al. Obesity and weight gain since early adulthood are associated with a lower risk of microscopic colitis. [Published online ahead of print December 7, 2018]. Clin Gastroenterol Hepatol. doi:10.1016/j.cgh.2018.11.057.
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