Clinical Edge

Summaries of Must-Read Clinical Literature, Guidelines, and FDA Actions

Obesity & Weight Gain in Risk of Microscopic Colitis

Clin Gastroenterol Hepatol; ePub 2018 Dec 7; Liu, et al

Obesity and weight gain since early adulthood are associated with lower risk of microscopic colitis, a new study found. In a prospective cohort study, researchers collected data from 192,101 women enrolled in the Nurses’ Health Study (NHS) or NHSII and examined the association between obesity and risk of microscopic colitis. They found:

  • There were 244 confirmed cases of microscopic colitis during 4,223,868 persons-years of follow up among participants in NHS and NHSII.
  • Higher body mass index (BMI) was inversely associated with risk of microscopic colitis.
  • Weight gain since early adulthood (age 18 years) was also inversely associated with risk of microscopic colitis.
  • The adjusted hazard ratio for each 10 kg weight gain since early adulthood was 0.85.
  • The associations were not modified by age, cohort, physical activity, or smoking status.

Citation:

Liu P-H, Burke KE, Ananthakrishnan AN, et al. Obesity and weight gain since early adulthood are associated with a lower risk of microscopic colitis. [Published online ahead of print December 7, 2018]. Clin Gastroenterol Hepatol. doi:10.1016/j.cgh.2018.11.057.

This Week's Must Reads

Frailty in Patients with Ascites & Hepatic Encephalopathy, Gastroenterology; ePub 2019 Jan 19; Lai, et al

DAA Therapy for HCV & Recurrence of HCC, Gastroenterology; ePub 2019 Jan 18; Singal, et al

Hypercholesterolemia & Statin Exposure in Cirrhosis, Gastroenterology; ePub 2019 Jan 18; Kaplan, et al

NAFLD as Cause of Mortality in Patients with HCC , J Clin Gastroenterol; ePub 2019 Jan 21; Hester, et al

Post-Diagnosis Statin Use & Mortality Risk in HCC, Clin Gastroenterol Hepatol; ePub 2019 Jan 6; Thrift, et al

Must Reads in IBD & Intestinal Disorders

Negative Events During Adulthood in Patients with IBS, Clin Gastroenterol Hepatol; ePub 2019 Jan 4; Parker, et al

Early Life Events & Risk of Developing IBS, J Clin Gastroenterol; ePub 2018 Dec 19; Ju, et al

Obesity & Weight Gain in Risk of Microscopic Colitis, Clin Gastroenterol Hepatol; ePub 2018 Dec 7; Liu, et al

Risk of Herpes Zoster With Pharmacotherapy for IBD , Clin Gastroenterol Hepatol; 2018 Dec; Khan, et al

Combination Therapy & Risk of IBD Complications, Clin Gastroenterol Hepatol; ePub 2018 Nov 15; Targownik, et al