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Negative Events During Adulthood in Patients with IBS

Clin Gastroenterol Hepatol; ePub 2019 Jan 4; Parker, et al

Negatively perceived adulthood life events are associated with an increased risk for irritable bowel syndrome (IBS), worse symptom severity and quality of life, and a dysregulated stress response. This according to a study of >200 participants in which researchers studied 129 patients with IBS (mean age 28.1 years, 66% women), and 108 healthy individuals (controls; mean age 29.8 years, 60% women) who completed the Life Experiences Survey from August 2013 to September 2017. They found:

  • Compared with controls, patients with IBS perceived more adulthood life events as negative and had a significantly higher negative life event impact score.
  • In patients with IBS, the presence of more negatively perceived adulthood life events was associated with worse IBS symptom severity and IBS-related quality of life.
  • Negatively perceived adulthood life events were associated with reduced production of adrenocorticotropic hormone (ACTH) in response to corticotrophin-releasing factor in those with IBS vs controls.

Citation:

Parker CH, Naliboff BD, Shih W, et al. Negative events during adulthood are associated with symptom severity and altered stress response in patients with irritable bowel syndrome. [Published online ahead of print January 4, 2019]. Clin Gastroenterol Hepatol. doi:10.1016/j.cgh.2018.12.029.