Clinical Edge

Summaries of Must-Read Clinical Literature, Guidelines, and FDA Actions

Menopausal Hormone Therapy Linked to Fecal Incontinence

Gastroenterology; ePub 2017 Feb 13; Staller, et al

Hormonal therapy may increase the risk of fecal incontinence in postmenopausal women, according to a recent review of data from the Nurses’ Health Study. The association between hormone therapy and fecal incontinence was gleaned from an analysis of 55,828 postmenopausal women with a mean age of 73 years. Incontinence was defined as one or more liquid or solid episodes a month during 4 years of follow-up, and based on questionnaires from nurses in 2010 and 2012. After analyzing more than 185,000 person-years of follow-up, investigators found:

  • Women who were past users of menopausal hormone therapy were about 26% more likely to develop incontinence (HR, 1.26) when compared to those who never used hormone therapy.
  • The risk of incontinence was greater among current users, with a HR of 1.32.
  • The risk was greater in women who took an estrogen/progestin combination (HR, 1.37), when compared to those who only took estrogen.

Citation:

Staller K, Townsend MK, Khalili H, et al. Menopausal hormone therapy is associated with increased risk of fecal incontinence in women after menopause. [Published online ahead of print February 13, 2017]. Gastroenterology. doi:10.1053/j.gastro.2017.02.005.

This Week's Must Reads

CRC Tumors & Genetic Testing in Minority Patients , Clin Gastroenterol Hepatol; ePub 2018 Aug 18; Muller, et al

Menopausal Risk Factors for Microscopic Colitis, Gastroenterology; ePub 2018 Aug 22; Burke, et al

Risk of HCC in Patients with NAFLD, Gastroenterology; ePub 2018 Aug 22; Kanwal, et al

Pharmacological Agents for Management of UC, Lancet Gastroenterol Hepatol; ePub 2018 Aug 16; Nguyen, et al

Disposable Transnasal Capsule Endoscopy for BE Screening, Clin Gastroenterol Hepatol; ePub 2018 Aug 3; Sami, et al

Must Reads in IBD & Intestinal Disorders

Pharmacological Agents for Management of UC, Lancet Gastroenterol Hepatol; ePub 2018 Aug 16; Nguyen, et al

Enteric Infections in Patients with Flares of IBD, Am J Gastroenterol; ePub 2018 Aug 3; Axelrad, et al

Autoimmune Disorders in People with Celiac Disease, J Clin Gastroenterol; ePub 2018 Jul 24; Kim, et al

Predictors of Suicidal Ideation in IBD Outpatients, J Clin Gastroenterol; ePub 2018 Jul 20; Hashash, et al

Obesity Burden & Hospitalization in IBD Patients, Clin Gastroenterol Hepatol; ePub 2018 Jul 15; Nguyen, et al