Clinical Edge

Summaries of Must-Read Clinical Literature, Guidelines, and FDA Actions

Early Life Events & Risk of Developing IBS

J Clin Gastroenterol; ePub 2018 Dec 19; Ju, et al

The traumatic severity of early adverse life events (EALs) and amount of confiding in others can affect the risk of having irritable bowel syndrome (IBS), a recent study found. 197 IBS patients (72% women, mean age 30.28 years) and 165 health controls completed the Childhood Traumatic Events Scale, measuring severity of EALs and degree of confiding in others. Regression analyses were used to predict IBS status from EALs and association between gastrointestinal symptoms and EALs. Researchers found:

  • More EALs and higher perceived trauma severity were associated with increased odds of IBS.
  • Confiding in others decreased the odds of having IBS.
  • The first age of EAL was not predictive of IBS.
  • No sex differences were found.


Ju T, Naliboff BD, Shih W, et al. Risk and protective factors related to early adverse life events in irritable bowel syndrome. [Published online ahead of print December 19, 2018]. J Clin Gastroenterol. doi:10.1097/MCG.0000000000001153.