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Dietary Gluten Intake & Risk of Microscopic Colitis

Am J Gastroenterol; ePub 2018 Sep 4; Liu, et al

Among women without celiac disease, dietary gluten intake during adulthood was not associated with risk of microscopic colitis, a recent study found. Researchers conducted a prospective study of 160,744 US women without celiac disease enrolled in the Nurses’ Health Study (NHS) and the NHSII. Dietary gluten intake was estimated using validated food frequency questionnaires every 4 years. Among the findings:

  • 219 incident cases of microscopic colitis were documented over >20 years of follow-up encompassing 3,716,718 person-years (crude incidence rate: 5.9/100,000 person-years) in NHS and NHSII.
  • Dietary gluten intake was not associated with risk of microscopic colitis.
  • The adjusted HR of microscopic colitis was 1.18 for the middle quintile and 1.03 for the highest quintile when compared to individuals in the lowest quintile of energy-adjusted gluten intake.
  • Additional adjustment for primary dietary sources did not materially alter the effect estimates.


Liu PH, Lebwohl B, Burke KE, et al. Dietary gluten intake and risk of microscopic colitis among US women without celiac disease: A prospective cohort study. [Published online ahead of print September 4, 2018]. Am J Gastroenterol. doi:10.1038/s41395-018-0267-5.