Clinical Edge

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Dietary Gluten Intake & Risk of Microscopic Colitis

Am J Gastroenterol; ePub 2018 Sep 4; Liu, et al

Among women without celiac disease, dietary gluten intake during adulthood was not associated with risk of microscopic colitis, a recent study found. Researchers conducted a prospective study of 160,744 US women without celiac disease enrolled in the Nurses’ Health Study (NHS) and the NHSII. Dietary gluten intake was estimated using validated food frequency questionnaires every 4 years. Among the findings:

  • 219 incident cases of microscopic colitis were documented over >20 years of follow-up encompassing 3,716,718 person-years (crude incidence rate: 5.9/100,000 person-years) in NHS and NHSII.
  • Dietary gluten intake was not associated with risk of microscopic colitis.
  • The adjusted HR of microscopic colitis was 1.18 for the middle quintile and 1.03 for the highest quintile when compared to individuals in the lowest quintile of energy-adjusted gluten intake.
  • Additional adjustment for primary dietary sources did not materially alter the effect estimates.

Citation:

Liu PH, Lebwohl B, Burke KE, et al. Dietary gluten intake and risk of microscopic colitis among US women without celiac disease: A prospective cohort study. [Published online ahead of print September 4, 2018]. Am J Gastroenterol. doi:10.1038/s41395-018-0267-5.

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