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Obesity and Diabetes as ICC Risk Factors

Am J Gastroenterol; ePub 2018 Sep 3; Petrick, et al

Obesity and diabetes are associated with increased intrahepatic cholangiocarcinoma (ICC) risk, a recent study found. The pooled analysis utilized the Liver Cancer Pooling Project (LCPP), a consortium of 13 US-based, prospective cohort studies with data from 1,541,143 individuals (n=414 ICC cases). Researchers identified 14 additional studies and conducted a meta-analysis, combining the results from LCPP with those from the 5 prospective studies identified through September 2017. They found:

  • In the LCPP, obesity and diabetes were associated with a 62% (HR=1.62) and an 81% (HR=1.81) increased ICC risk, respectively.
  • In the meta-analysis of prospectively ascertained cohorts and nested case-control studies, obesity was associated with a 49% increased ICC risk (relative risk [RR]=1.49).
  • Diabetes was associated with a 53% increased ICC risk (RR=1.53).
  • Results were consistent in subgroup analyses.


Petrick JL, Thistle JE, McGlynn KA, et al. Body mass index, diabetes and intrahepatic cholangiocarcinoma risk: The Liver Cancer Pooling Project and meta-analysis. [Published online ahead of print September 3, 2018]. Am J Gastroenterol. doi:10.1038/s41395-018-0207-4.