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NASH Leading Cause of HCC in LT Patients

Clin Gastroenterol Hepatol; ePub 2018 Jun 13; Younossi, et al

Non-alcoholic steatohepatitis (NASH) is the most rapidly growing cause of hepatocellular carcinoma (HCC) among US patients listed for liver transplantation (LT), a recent study found. Researchers used the Scientific Registry of Transplant Recipients (2002-2016) to estimate the trends in prevalence of HCC in LT candidates with the most common types of chronic liver disease: alcoholic liver disease (ALD), chronic hepatitis B (CHB), chronic hepatitis C (CHC), and NASH. They found:

  • 158,347 adult LT candidates were included in the study (16.5% had HCC; this proportion increased from 6.4% in 2002 to 23.0% in 2016).
  • CHC remained the most common etiology for HCC (65%) over the study period.
  • The proportions of HCC accounted for by CHC and ALD remained stable, the proportion of CHB decreased 3.1-fold, while the proportion of NASH in HCC increased 7.7-fold.
  • Moreover, since 2002, the prevalence of HCC in LT candidates with NASH increased 11.8-fold.

Citation:

Younossi Z, Stepanova M, Ong JP, et al. Non-alcoholic steatohepatitis it the fastest growing cause of hepatocellular carcinoma in liver transplant candidates. [Published online ahead of print June 13, 2018]. Clin Gastroenterol Hepatol. doi:10.1016/j.cgh.2018.05.057.

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