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Loss of pancreatic E-cadherin contributes to carcinogenesis

Key clinical point: Loss of pancreatic E-cadherin may interfere with normal growth and maintenance of the pancreas and contributes to multiple pathological processes, including carcinogenesis.

Major finding: All mice lacking pancreatic E-cadherin died within 28 days.

Study details: A mouse model and cell line study investigating E-cadherin in the pancreas.

Disclosures: The study was funded by the Japan Society for the Promotion of Science KAKENHI grant JP17K09465 and the Yokohama (Japan) City University Kamome project. The investigators declared no conflicts of interest.


Kaneta Y et al. Cell Mol Gastroenterol Hepatol. 2019 Sep 14. doi: 10.1016/j.jcmgh.2019.09.001.