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Family History & Risk of CRC in Patients with IBD

Clin Gastroenterol Hepatol; ePub 2018 Sep 26; Samadder, et al

Among patients with inflammatory bowel diseases (IBD) with a family history of colorectal cancer (CRC) in a first-degree relative (FDR), there is a marked increased risk of CRC, according to a recent study. A cohort of Utah residents with IBD was identified from Intermountain Healthcare and University of Utah Health Sciences between January 1, 1996 and December 31, 2011. CRC incidence was compared with that of the state population by standardized incidence rates (SIRs). Researchers found:

  • Among 9,505 individuals identified with IBD, 101 developed CRC during the study period.
  • There was an increased SIR of CRC in both Crohn’s disease (3.4) and ulcerative colitis (5.2) patients.
  • Individuals with a concurrent diagnosis of PSC had the greatest risk of CRC (14.8).
  • A family history of CRC in a FDR was associated with a nearly 8-fold increased risk of CRC in patients with IBD.


Samadder NJ, Valentine JF, Guthery S, et al. Family history is associated with increased risk of colorectal cancer in patients with inflammatory bowel diseases. [Published online ahead of print September 26, 2018]. Clin Gastroenterol Hepatol. doi:10.1016/j.cgh.2018.09.038.