Clinical Edge

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Esophageal & Gastric Cancer Subtypes by Race

Clin Gastroenterol Hepatol; 2019 Feb; Islami, et al

In a recent analysis of high-quality nationwide population-based data, researchers found increasing trends for esophageal adenocarcinoma (EAC), gastric cardia adenocarcinoma (GCA), and gastric non-cardia adenocarcinoma (GNCA) in several subpopulations in the US. Average contemporary incidence rates (2010‒2014) and annual percent changes in rates (from 1997‒2014) by race, ethnicity, and age were calculated for each cancer subtype. Researchers found:

  • From 1997-2014, overall esophageal squamous cell carcinoma incidence rates continuously decreased in both sexes and all racial and ethnic groups, although rates remained stable among younger non-Hispanic white women.
  • Overall, EAC incidence rates decreased or stabilized during the most recent time period (2006‒2007 through 2014) in men and women.
  • However, EAC incidence rates continued to increase from 1997-2014 in several subpopulations, including non-Hispanic white men aged <50 years, non-Hispanic white women aged <70 years, and Asian/Pacific Islander men.
  • Overall, GCA incidence rates increased among non-Hispanic whites, but decreased among Hispanics and Asian/Pacific Islanders.
  • Overall GNCA rates decreased in both sexes and all racial and ethnic groups.


Islami F, DeSantis CE, Jemal A. Incidence trends of esophageal and gastric cancer subtypes by race, ethnicity, and age in the United States, 1997-2014. Clin Gastroenterol Hepatol. 2019;17:429-439. doi:10.1016/j.cgh.2018.05.044.