Clinical Edge

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Dietary Patterns and Risk of HCC in US Adults

Hepatology; ePub 2018 Dec 1; Ma, Yang, et al

Among US adults, better adherence to the Alternative Healthy Eating Index-2010 (AHEI-2010) may decrease the risk of developing hepatocellular carcinoma (HCC), a recent study found. Researchers assessed the associations of 3 key commonly used a priori dietary patterns, the AHEI-2010, Alternate Mediterranean Diet (AMED), and Dietary Approaches to Stop Hypertension (DASH) with risk of incident HCC in the Health Professionals Follow-up Study and the Nurses’ Health Study. Diet was assessed almost every 4 years. They found:

  • During up to 32 years of follow-up, 160 incident HCC cases were identified.
  • After adjustment for most HCC risk factors, participants in the highest tertile of AHEI-2010 had a multivariable hazard ratio (HR) of 0.61, compared with those in the lowest tertile.
  • There was a suggestive but nonsignificant inverse association for AMED, and a null association for DASH in relation to the risk of HCC development.


Ma Y, Yang W, Simon TG, et al. Dietary patterns and risk of hepatocellular carcinoma among US men and women. [Published online ahead of print December 1, 2019]. Hepatology. doi:10.1002/hep.30362.