Clinical Edge

Summaries of Must-Read Clinical Literature, Guidelines, and FDA Actions

Dietary Patterns and Risk of HCC in US Adults

Hepatology; ePub 2018 Dec 1; Ma, Yang, et al

Among US adults, better adherence to the Alternative Healthy Eating Index-2010 (AHEI-2010) may decrease the risk of developing hepatocellular carcinoma (HCC), a recent study found. Researchers assessed the associations of 3 key commonly used a priori dietary patterns, the AHEI-2010, Alternate Mediterranean Diet (AMED), and Dietary Approaches to Stop Hypertension (DASH) with risk of incident HCC in the Health Professionals Follow-up Study and the Nurses’ Health Study. Diet was assessed almost every 4 years. They found:

  • During up to 32 years of follow-up, 160 incident HCC cases were identified.
  • After adjustment for most HCC risk factors, participants in the highest tertile of AHEI-2010 had a multivariable hazard ratio (HR) of 0.61, compared with those in the lowest tertile.
  • There was a suggestive but nonsignificant inverse association for AMED, and a null association for DASH in relation to the risk of HCC development.

Citation:

Ma Y, Yang W, Simon TG, et al. Dietary patterns and risk of hepatocellular carcinoma among US men and women. [Published online ahead of print December 1, 2019]. Hepatology. doi:10.1002/hep.30362.

This Week's Must Reads

Frailty in Patients with Ascites & Hepatic Encephalopathy, Gastroenterology; ePub 2019 Jan 19; Lai, et al

DAA Therapy for HCV & Recurrence of HCC, Gastroenterology; ePub 2019 Jan 18; Singal, et al

Hypercholesterolemia & Statin Exposure in Cirrhosis, Gastroenterology; ePub 2019 Jan 18; Kaplan, et al

NAFLD as Cause of Mortality in Patients with HCC , J Clin Gastroenterol; ePub 2019 Jan 21; Hester, et al

Post-Diagnosis Statin Use & Mortality Risk in HCC, Clin Gastroenterol Hepatol; ePub 2019 Jan 6; Thrift, et al

Must Reads in GI Oncology

DAA Therapy for HCV & Recurrence of HCC, Gastroenterology; ePub 2019 Jan 18; Singal, et al

NAFLD as Cause of Mortality in Patients with HCC , J Clin Gastroenterol; ePub 2019 Jan 21; Hester, et al

Post-Diagnosis Statin Use & Mortality Risk in HCC, Clin Gastroenterol Hepatol; ePub 2019 Jan 6; Thrift, et al

Dietary Patterns and Risk of HCC in US Adults, Hepatology; ePub 2018 Dec 1; Ma, Yang, et al

Incidence Trends of GEP-NETs in the US, Clin Gastroenterol Hepatol; ePub 2018 Dec 20; Lee, et al