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CRC Tumors & Genetic Testing in Minority Patients

Clin Gastroenterol Hepatol; ePub 2018 Aug 18; Muller, et al

Minority patients are less likely to be recommended for genetic evaluation or undergo germline testing for Lynch syndrome despite similar rates of colorectal tumor analysis, a recent study showed. Researchers performed a retrospective analysis of colorectal tumors tested from 2012 through 2016 as 4 academic centers. Tumor samples were collected from 767 patients with colorectal cancer (52% non-Hispanic white [NHW], 26% African American, and 17% Hispanic patients). They assessed rates of tumor testing, recommendations for genetic evaluation, rates of attending a genetic evaluation, and performance of germline testing overall and by race/ethnicity. Among the findings:

  • Overall, 92% of colorectal tumors were analyzed for mismatch repair deficiency without significant differences among races/ethnicities.
  • However, minority patients were significantly less likely to be referred for genetic evaluation (21.2% for NHW patients; 17.0% for African American patients; and 11.0% for Hispanic patients).
  • Rates of genetic testing were also lower among minority patients.
  • Older age, African American race, and medical center were independently associated with lack of referral for genetic evaluation and genetic testing.

Citation:

Muller C, Lee SM, Barge W, et al. Low referral rate for genetic testing in racially and ethnically diverse patients despite universal colorectal cancer screening. [Published online ahead of print August 18, 2018]. Clin Gastroenterol Hepatol. doi:10.1016/j.cgh.2018.08.038.

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