Key clinical point: Among individuals with primary sclerosing cholangitis and inflammatory bowel disease, younger age at diagnosis, male sex, and Afro-Caribbean heritage were significant risk factors for liver transplantation and disease-related death.
Major finding: Individuals who were diagnosed with primary sclerosing cholangitis when younger than 40 years had a more than sevenfold higher death rate, compared with those who had inflammatory bowel disease alone.
Study details: Ten-year prospective population-based study of 284,560 patients with inflammatory bowel disease, of whom 2,588 also had primary sclerosing cholangitis.
Disclosures: Dr. Trivedi disclosed support from the National Institute for Health Research Birmingham Biomedical Research Centre, at the University Hospitals Birmingham NHS Foundation Trust and the University of Birmingham. No other disclosures were reported.
Trivedi PJ et al. Gastroenterology. 2020 May 19. doi: 10.1053/j.gastro.2020.05.049.