Clinical Edge

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Mailed fecal testing may catch more cancer than endoscopic screening

Key clinical point: On a population level, mailed fecal testing could catch more cases of advanced neoplasia than endoscopic screening methods.

Major finding: On a population level, mailed fecal immunohistochemical tests had a cumulative diagnostic yield of 4.5%, compared with 2.3% for sigmoidoscopy and 2.2% for colonoscopy.

Study details: A prospective study involving 30,052 screening-naive people.

Disclosures: The study was funded by The Netherlands Organization for Health Research and Development. The investigators disclosed no conflicts of interest.


Grobbee EJ et al. Clin Gastro Hepatol. 2019 Aug 13. doi: 10.1016/j.cgh.2019.08.015.