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Response to UDCA Treatment in PBC Patients

Clin Gastroenterol Hepatol; ePub 2019 Jan 4; Cheung, et al

In patients with primary biliary cholangitis (PBC), patient age, but not sex, is associated with response to ursodeoxycholic acid (UDCA) and transplant-free survival. This according to a longitudinal analysis of 4,355 adults in the Global PBC Study cohort, collected from 17 centers across Europe and North America. Researchers evaluated the effects of sex and age on response to UDCA treatment and transplant-free survival using logistic regression and Cox regression analyses, respectively. The found:

  • Younger age at time of PBC diagnosis was associated with increased risk of failure treatment, liver transplant, and death.
  • The greatest odds of response to UDCA were observed in patients aged >65 years.
  • Risk of liver transplant or death decreased significantly with advancing age.
  • Sex was not independently associated with response or transplant-free survival.


Cheung AC, Lammers WJ, Perez CFM, et al. Effects of age and sex of on response to ursodeoxycholic acid and transplant-free survival in patients with primary biliary cholangitis. [Published online ahead of print January 4, 2019]. Clin Gastroenterol Hepatol. doi:10.1016/j.cgh.2018.12.028.