Individuals with hepatic steatosis without known liver disease had higher mean serum concentrations of systemic markers of inflammation, a recent study found. The community-based cohort included data from 2,482 participants from the Framingham Heart Study (mean age 51 ±11 years; 51% women) who underwent computed tomography and measurement of 14 serum markers of systemic inflammation. Primary covariates included age, sex, smoking, alcohol, aspirin use, hypertension, dyslipidemia, diabetes, and cardiovascular disease. Researchers found:
- In multivariable-adjusted models, liver fat was associated with the following inflammatory markers: high-sensitivity C-reactive protein, urinary isoprostanes, interleukin 6, intercellular adhesion molecule 1, and P-selectin.
- Additional adjustment for body mass index (BMI) or visceral fat attenuated the results slightly; however, all associations remained statistically significant.
Fricker AP, Pedley A, Massaro JM, et al. Liver fat is associated with markers of inflammation and oxidative stress in analysis of data from the Framingham Heart Study. [Published online ahead of print November 23, 2018]. Clin Gastroenterol Hepatol. doi:10.1016/j.cgh.2018.11.037.
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