Clinical Edge

Summaries of Must-Read Clinical Literature, Guidelines, and FDA Actions

Markers of Inflammation in Hepatic Steatosis

Clin Gastroenterol Hepatol; ePub 2018 Nov 23; Fricker, et al

Individuals with hepatic steatosis without known liver disease had higher mean serum concentrations of systemic markers of inflammation, a recent study found. The community-based cohort included data from 2,482 participants from the Framingham Heart Study (mean age 51 ±11 years; 51% women) who underwent computed tomography and measurement of 14 serum markers of systemic inflammation. Primary covariates included age, sex, smoking, alcohol, aspirin use, hypertension, dyslipidemia, diabetes, and cardiovascular disease. Researchers found:

  • In multivariable-adjusted models, liver fat was associated with the following inflammatory markers: high-sensitivity C-reactive protein, urinary isoprostanes, interleukin 6, intercellular adhesion molecule 1, and P-selectin.
  • Additional adjustment for body mass index (BMI) or visceral fat attenuated the results slightly; however, all associations remained statistically significant.


Fricker AP, Pedley A, Massaro JM, et al. Liver fat is associated with markers of inflammation and oxidative stress in analysis of data from the Framingham Heart Study. [Published online ahead of print November 23, 2018]. Clin Gastroenterol Hepatol. doi:10.1016/j.cgh.2018.11.037.

Must Reads in Endoscopy, Pancreas, & Biliary Tract

Gender Differences in Patients Hospitalized with Cirrhosis, J Clin Gastroenterol; ePub 2019 Feb 22; Rubin, et al

POC Test for Identifying Viraemic HCV Infection, J Hepatol; ePub 2019 Feb 21; Freiman, et al

Frailty in Patients with Ascites & Hepatic Encephalopathy, Gastroenterology; ePub 2019 Jan 19; Lai, et al

Hypercholesterolemia & Statin Exposure in Cirrhosis, Gastroenterology; ePub 2019 Jan 18; Kaplan, et al

Response to UDCA Treatment in PBC Patients, Clin Gastroenterol Hepatol; ePub 2019 Jan 4; Cheung, et al