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Markers of Inflammation in Hepatic Steatosis

Clin Gastroenterol Hepatol; ePub 2018 Nov 23; Fricker, et al

Individuals with hepatic steatosis without known liver disease had higher mean serum concentrations of systemic markers of inflammation, a recent study found. The community-based cohort included data from 2,482 participants from the Framingham Heart Study (mean age 51 ±11 years; 51% women) who underwent computed tomography and measurement of 14 serum markers of systemic inflammation. Primary covariates included age, sex, smoking, alcohol, aspirin use, hypertension, dyslipidemia, diabetes, and cardiovascular disease. Researchers found:

  • In multivariable-adjusted models, liver fat was associated with the following inflammatory markers: high-sensitivity C-reactive protein, urinary isoprostanes, interleukin 6, intercellular adhesion molecule 1, and P-selectin.
  • Additional adjustment for body mass index (BMI) or visceral fat attenuated the results slightly; however, all associations remained statistically significant.

Citation:

Fricker AP, Pedley A, Massaro JM, et al. Liver fat is associated with markers of inflammation and oxidative stress in analysis of data from the Framingham Heart Study. [Published online ahead of print November 23, 2018]. Clin Gastroenterol Hepatol. doi:10.1016/j.cgh.2018.11.037.

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