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Lactation Duration & Prevalence of NAFLD

J Hepatol; ePub 2018 Nov 1; Ajmera, et al

A longer duration of lactation (> 6 months) is associated with lower odds of non-alcoholic fatty liver disease (NAFLD) in mid-life women and may represent a modifiable risk factor for NAFLD, a recent study found. Participants from the Coronary Artery Risk Development in Young Adults cohort study who delivered ≥1 child post-baseline and underwent CT quantification of hepatic steatosis 25 years following cohort entry were included. Among the findings:

  • Of 844 women who delivered after baseline, 32% reported lactation duration 0 to 1 month, 25% reported >1 to 6 months, 43% reported >6 months, while 54 (6% had NAFLD.
  • Lactation duration >6 months was protective against NAFLD in mid-life after adjustment for confounders.
  • The benefits of increased lactation duration on weight and waist circumference mediated < one-fourth of this benefit.


Ajmera VH, Terrault NA, VanWagner LB, et al. Longer lactation duration is associated with decreased prevalence of non-alcoholic fatty liver disease in women. [Published online ahead of print November 1, 2018]. J Hepatol. doi:10.1016/j.jhep.2018.09.013.