Clinical Edge

Summaries of Must-Read Clinical Literature, Guidelines, and FDA Actions

Lactation Duration & Prevalence of NAFLD

J Hepatol; ePub 2018 Nov 1; Ajmera, et al

A longer duration of lactation (> 6 months) is associated with lower odds of non-alcoholic fatty liver disease (NAFLD) in mid-life women and may represent a modifiable risk factor for NAFLD, a recent study found. Participants from the Coronary Artery Risk Development in Young Adults cohort study who delivered ≥1 child post-baseline and underwent CT quantification of hepatic steatosis 25 years following cohort entry were included. Among the findings:

  • Of 844 women who delivered after baseline, 32% reported lactation duration 0 to 1 month, 25% reported >1 to 6 months, 43% reported >6 months, while 54 (6% had NAFLD.
  • Lactation duration >6 months was protective against NAFLD in mid-life after adjustment for confounders.
  • The benefits of increased lactation duration on weight and waist circumference mediated < one-fourth of this benefit.

Citation:

Ajmera VH, Terrault NA, VanWagner LB, et al. Longer lactation duration is associated with decreased prevalence of non-alcoholic fatty liver disease in women. [Published online ahead of print November 1, 2018]. J Hepatol. doi:10.1016/j.jhep.2018.09.013.

This Week's Must Reads

Dietary Patterns and Risk of HCC in US Adults, Hepatology; ePub 2018 Dec 1; Ma, Yang, et al

Early Life Events & Risk of Developing IBS, J Clin Gastroenterol; ePub 2018 Dec 19; Ju, et al

Short-Term Mortality of Acute-on-Chronic Liver Failure, J Hepatol; ePub 2018 Dec 24; Hernaez, et al

Incidence Trends of GEP-NETs in the US, Clin Gastroenterol Hepatol; ePub 2018 Dec 20; Lee, et al

Risk of Advanced Liver Disease in Hispanics , Clin Gastroenterol Hepatol; ePub 2018 Dec 7; Turner, et al

Must Reads in Endoscopy, Pancreas, & Biliary Tract

Short-Term Mortality of Acute-on-Chronic Liver Failure, J Hepatol; ePub 2018 Dec 24; Hernaez, et al

Incidence Trends of GEP-NETs in the US, Clin Gastroenterol Hepatol; ePub 2018 Dec 20; Lee, et al

Preoperative ERCP & Increased Pancreatic Cancer Mortality, Clin Gastroenterol Hepatol; ePub 2018 Dec 7; Rustgi, et al

Markers of Inflammation in Hepatic Steatosis, Clin Gastroenterol Hepatol; ePub 2018 Nov 23; Fricker, et al

Lactation Duration & Prevalence of NAFLD , J Hepatol; ePub 2018 Nov 1; Ajmera, et al