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Incidence Trends of GEP-NETs in the US

Clin Gastroenterol Hepatol; ePub 2018 Dec 20; Lee, et al

In the US, the incidence of gastroenteropancreatic neuroendocrine tumors (GEP-NETs) continues to increase, especially among older adults. This according to a recent study that examined incidence trends of GEP-NETs in the US from 1975 through 2012. Researchers calculated overall annual incidence, age-adjusted incidence, annual percent change (APC), and average APC by 5-year age intervals. They found:

  • 22,744 patients with GEP-NETs were identified.
  • In adults aged 25‒39 years, GEP-NET incidence rates decreased from the mid-1970s to the early 1980s, then increased until 2012.
  • In adults aged ≥40 years or young adults aged 15‒24 years, incidence rates generally increased continuously from 1975 through 2012.
  • Adults aged 40-60 years had to the most rapid increases in average APC.
  • Overall incidence rates were highest in those 70‒84 years.


Lee MR, Harris C, Baeg KJ, et al. Incidence trends of gastroenteropancreatic neuroendocrine tumors in the United States. [Published online ahead of print December 20, 2018]. Clin Gastroenterol Hepatol. doi:10.1016/j.cgh.2018.12.017.