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Gender Differences in Patients Hospitalized with Cirrhosis

J Clin Gastroenterol; ePub 2019 Feb 22; Rubin, et al

In patients hospitalized with cirrhosis in the US, women had lower rates of hepatic decompensating events and higher rates of nonhepatic comorbidities and infections than men, resulting in lower in-hospital mortality. Researchers analyzed data from the National Inpatient Sample (NIS), years 2009‒2013, to identify patients with any diagnosis of cirrhosis. The primary outcome was inpatient mortality. Among the details:

  • The cohort included 553,017 patients with cirrhosis (39% women; median age 57; 66% non-Hispanic white) admitted from 2009‒2013.
  • Women were more likely than men to have noncirrhosis comorbidities, including diabetes and hypertension, but less likely to have most cirrhosis complications, including ascites and variceal bleeding.
  • Women were more likely to have acute bacterial infections but were less likely than men to die in the hospital.


Rubin J, Sundaram V, Lai JC. Gender differences among patients hospitalized with cirrhosis in the United States. [Published online ahead of print February 22, 2019]. J Clin Gastroenterol. doi:10.1097/MCG.0000000000001192.