Clinical Edge

Summaries of Must-Read Clinical Literature, Guidelines, and FDA Actions

How to Manage Duodenal Crohn’s Disease

Inflamm Bowel Dis; 2018 Feb 15; Lightner

The best approach to duodenal Crohn’s disease remains somewhat subjective but experts have provided some guidelines on how to manage the disorder, according to a recent review. Investigators found:

  • Although symptomatic duodenal Crohn’s disease is rare, when it does occur, it usually involves stricturing rather than inflammation or perforation.
  • Most patients do not present with symptoms, which is why the disease is typically detected during imaging or endoscopy performed for other reasons.
  • Non-surgical treatment includes proton pump inhibitors, corticosteroids, immunomodulatory drugs, and biologics.
  • If the patient has symptomatic strictures, they can often be managed medically or endoscopically.

Lightner AL. Duodenal Crohn's disease. Inflamm Bowel Dis. 2018;24(3):546-551. doi:10.1093/ibd/izx083.

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Ustekinumab & Health-Related Quality of Life in CD, J Crohns Colitis; ePub 2018 May 3; Sands, et al

Increased Risk of Acute MI and HF with IBD, Clin Gastroenterol Hepatol; ePub 2018 Apr 24; Aniwan, et al

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Clinical Course of IBD with Celiac Disease, J Crohns Colitis; ePub 2018 May 7; Tse, et al

Incidence of Intestinal Infections in IBD, Inflamm Bowel Dis; ePub 2018 May 2; Barber, et al