Clinical Edge

Summaries of Must-Read Clinical Literature, Guidelines, and FDA Actions

AGA Clinical Practice Update: Per-Oral Endoscopic Myotomy for Achalasia

Gastroenterology; 2017 Nov; Kahrilas, et al

The latest advice from the American Gastroenterological Association (AGA) on the use of per-oral endoscopic myotomy includes the following recommendations:

  • Practitioners should consider patient-specific parameters when attempting to assess the need for achalasia therapy, including Chicago Classification subtype, the presence of co-existing disorders, whether the patient has early or late disease, and whether there are primary or secondary causes involved.
  • Per-oral endoscopic myotomy is a complex procedure that should be performed by experienced physicians in high volume treatment centers who have had an estimated 20-40 procedures under their belt.
  • Per-oral endoscopic myotomy should be viewed as primary therapy among patients with type III achalasia, assuming the physician has adequate experience.


Kahrilas PJ, Katzka D, Richter JE. Clinical Practice Update: The use of per-oral endoscopic myotomy in achalasia: Expert review and best practice advice from the AGA Institute. Gastroenterology. 2017;153:1205-1211. doi:10.1053/j.gastro.2017.10.001.

This Week's Must Reads

How to Manage Duodenal Crohn’s Disease , Inflamm Bowel Dis; 2018 Feb 15; Lightner

Don’t Ignore Iron Deficiency in IBD Patients, Rev Esp Enferm Dig; ePub 2018 Feb 21; Casellas, et al

Hiring Scribes to Handle EHRs Frees Physicians, Inflamm Bowel Dis; 2018 Feb 15; Ewelukwa, et al

IBD Linked to Several Monogenic Disorders, Inflamm Bowel Dis; 2018 Feb 15; Han, et al

Link Between IBD, Cholangitis & Colorectal CA, Clin Gastroenterol Hepatol; ePub 2018 Feb 4; Ricciuto, et al

Must Reads in Clinical Guidelines

AGA Guideline: Drug Monitoring in IBD, Gastroenterology; 2017 Sep; Feuerstein, et al

AGA Clinical Practice Update: Tx for Fecal Incontinence, Clin Gastroenterol Hepatol; 2017 Dec; Bharucha, et al

ACG/CAG Updates Guidelines on Dyspepsia, Am J Gastroenterol; ePub 2017 Jun 20; Moayyedi, et al

EGFR Inhibitors Benefit Metastatic CRC Patients, Cochrane; 2017 Jun 27; Chan, et al