Q1. Correct Answer: A
This patient has an idiopathic, non-NSAID, non-H. pylori-associated ulcer and should be on daily PPI indefinitely. These patients have a high rate of recurrent bleeding (42%) and mortality when followed prospectively without being on antisecretory therapy. Although no randomized trials have assessed the benefit of medical cotherapy in this population, antiulcer therapy seems to reduce recurrent idiopathic ulcers.
1. Wong G.L.H., Wong V.W.S. Chan Y., et al. High incidence of mortality and recurrent bleeding in patients with Helicobacter pylori-negative idiopathic bleeding ulcers. Gastroenterology. 2009;137:525-31.
2. Laine L. Jensen D.M. Management of patients with ulcer bleeding. Am J Gastroenterol. 2012;107:345-60.