Clinical Edge

Summaries of Must-Read Clinical Literature, Guidelines, and FDA Actions

Short Interpregnancy Intervals & Pregnancy Outcomes

JAMA Intern Med; ePub 2018 Oct 29; Schummers, et al

Short interpregnancy intervals are associated with increased risks for adverse pregnancy outcomes for women of all ages, a new study found. The population-based cohort study of 148,544 pregnancies evaluated women with ≥2 singleton pregnancies from 2004 to 2014 with the first (index) pregnancy resulting in a live birth. Researchers found:

  • Maternal mortality or severe morbidity risks were increased at short interpregnancy intervals among women aged ≥35 years but not for women aged 20‒34 years.
  • Conversely, increased risks of adverse fetal and infant outcomes and spontaneous preterm delivery were more pronounced for women aged 20‒34 years than for women aged ≥35 years.
  • Modest increases in risks of small-for-gestational age and indicated preterm delivery at short intervals did not vary meaningfully by maternal age.

Citation:

Schummers L, Hutcheon JA, Hernandez-Diaz S, et al. Association of short interpregnancy interval with pregnancy outcomes according to maternal age. [Published online ahead of print October 29, 2018]. JAMA Intern Med. doi:10.1001/jamainternmed.2018.4696.

This Week's Must Reads

Patient-Centered Intervention for Prostate Ca Care, J Clin Oncol; ePub 2019 Mar 12; Jayadevappa, et al

Subsequent Cancer Risk in Prostate Cancer, Lancet Oncol; ePub 2019 Mar 15; Mohamad, et al

Accuracy of 68Ga-PSMA-11 PET in Prostate Cancer, JAMA Oncol; ePub 2019 Mar 28; Fendler, et al

Low Muscle Mass in Patients with Prostate Cancer, J Urol; ePub 2019 Mar 27; Pak, Park, et al

Steroid Hormones & Progression of Prostate Cancer, Cancer Epidemiol Biomarkers Prev; ePub 2019 Mar 27; Lévesque, et al

Must Reads in Women's Health

Pregnancy History and Risk of Miscarriage, BMJ; ePub 2019 Mar 20; Magnus, et al

Ultrasonography Screening in Breast Cancer, JAMA Intern Med; ePub 2019 Mar 18; Lee, et al

Sedentary Behaviors & CVD Risk in Older Women, Circulation; 2019 Feb 19; Bellettiere, et al

USPSTF: Interventions to Avert Perinatal Depression, JAMA; 2019 Feb 12; US Preventive Services Task Force

Hypertensive Diseases of Pregnancy & Risk of HF, Mayo Clin Proc; ePub 2018 Dec 19; Nizamuddin, et al