Clinical Edge

Summaries of Must-Read Clinical Literature, Guidelines, and FDA Actions

Increased Water Intake in Premenopausal Women with UTIs

JAMA Intern Med; ePub 2018 Oct 1; Hooton, et al

Increased daily water intake protects against recurrent cystitis in premenopausal women who drink low volumes of fluid daily, a recent study found. The randomized, open-label, controlled 12-month trial included 140 healthy women with recurrent cystitis. Participants were randomly assigned to drink, in addition to their usual fluid intake, 1.5 L of water daily (water group) or no additional fluids (control group) for 12 months. Assessments of daily fluid intake, urinary hydration, and cystitis symptoms were performed at baseline, 6- and 12-month visits, and monthly telephone calls. Researchers found:

  • The mean age of the 140 study participants was 35.7 years, and the mean number of cystitis episodes in the previous year was 3.3.
  • Cystitis episodes were significantly less frequent in women who drank more water for 12 months compared with women who maintained their usual fluid intake.
  • Overall, there were 327 cystitis episodes, 111 in the water group and 216 in the control group.
  • The mean number of antimicrobial regimens used to treat cystitis episodes was 1.9 in the water group and 3.6 in the control group, with a difference in means of 1.7.

Citation:

Hooton TM, Vecchio M, Iroz A, et al. Effect of increased daily water intake in premenopausal women with recurrent urinary tract infections. A randomized clinical trial. [Published online ahead of print October 1, 2018.]. JAMA Intern Med. doi:10.1001/jamainternmed.2018.4204.

This Week's Must Reads

Treating Low-Risk Patients with Mild Hypertension, JAMA Intern Med; ePub 2018 Oct 29; Sheppard, et al

Short Interpregnancy Intervals & Pregnancy Outcomes, JAMA Intern Med; ePub 2018 Oct 29; Schummers, et al

Peer Support Impact in Adults with T2D & Depression, Diabetes Care; ePub 2018 Oct 29; Cherrington, et al

Efficacy of Bariatric Procedures for Weight Loss, Ann Intern Med; ePub 2018 Oct 30; Arterburn, et al

Concomitant DOAC-Antiplatelet Use & Bleeding Risk, Am J Med; ePub 2018 Oct 25; Douros, et al

Must Reads in Women's Health

Short Interpregnancy Intervals & Pregnancy Outcomes, JAMA Intern Med; ePub 2018 Oct 29; Schummers, et al

USPSTF: Screening for Intimate Partner Violence, JAMA; 2018 Oct 23/30; US Preventive Services Task Force

Maternal Beta-Blocker Use & Risk of Malformations, Ann Intern Med; ePub 2018 Oct 16; Bateman, et al

Delayed Pushing & Spontaneous Vaginal Delivery , JAMA; 2018 Oct 9; Cahill, Srinivas, et al

Increased Water Intake in Premenopausal Women with UTIs, JAMA Intern Med; ePub 2018 Oct 1; Hooton, et al