Key clinical point: Androgen deprivation therapy has been known to have a negative effect on cognitive function, however, data are conflicting and an association between ADT and cognitive dysfunction remains unconfirmed.
Major finding: In a longitudinal study of 2,974 men, bioavailable testosterone was not associated with increased dementia risk, but higher levels of bioavailable estradiol were significant predictors of Alzheimer’s disease.
Study details: The data come from a review of recent studies involving androgen deprivation therapy to treat prostate cancer.
Disclosures: The study received no outside funding. The researchers had no financial conflicts to disclose.
Shim M et al. Prostate Int. 2021 Mar 9. doi: 10.1016/j.prnil.2021.02.002.