Key clinical point: Characterization of the androgen receptor-gene landscape and gene alterations provides potential insight into the somatic genetic heterogeneity of advanced prostate cancer.
Major finding: A total of 112 androgen-receptor gene mutations were identified in patients with advanced prostate cancer.
Study details: A total of 892 patients that underwent Guardant360 testing with advanced prostate cancer were included. Androgen-reception gene mutations were identified in circulating tumor DNA after the testing of 54 to 73 genes.
Disclosures: None reported.
Ledet EM, et al. Oncologist. 2019 Nov 11. doi: 10.1634/theoncologist.2019-0115. [Epub ahead of print]