Clinical Edge

Summaries of Must-Read Clinical Literature, Guidelines, and FDA Actions

Breast Biopsy Rates Following BC Screening

JAMA Intern Med; 2018 Apr; Buist, et al

Women with and without a personal history of breast cancer (PHBC) who undergo screening magnetic resonance imaging (MRI) experience higher biopsy rates coupled with significantly lower cancer yield compared with screening mammography alone, a recent study found. The population-based cohort included 812,164 women undergoing screening (mammography vs MRI with or without mammography) from 2003 through 2013. A total of 2,048,994 digital mammography and/or breast MRI screening episodes were observed. Researchers found:

  • Age-adjusted core and surgical biopsy rates per 1,000 episodes doubled following MRI compared with mammography in women with PHBC.
  • Differences were even larger in women without PHBC: 84.7 following MRI and 14.9 following mammography episodes.
  • Lower invasive cancer and ductal carcinoma in situ yield for both groups was observed.
  • Higher biopsy rates and lower cancer yield following MRI was not explained by increasing age or higher 5-year breast cancer risk.


Buist DSM, Abraham L, Lee CI, et al. Breast biopsy intensity and findings following breast cancer screening in women with and without a personal history of breast cancer. JAMA Intern Med. 2018;178(4):458–468. doi:10.1001/jamainternmed.2017.8549.

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Burden of Diseases & Risk Factors Among US States, JAMA; 2018 Apr 10; US Burden of Disease Collaborators

Cardiorespiratory Fitness & All-Cancer Mortality, Mayo Clin Proc; ePub 2018 Mar 27; Wang, et al