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NSAID Exposure Linked by Incident Kidney Problems

JAMA Netw Open; 2019 Feb 15; Nelson, et al

In a large cohort of active young and middle-aged adults, modest but statistically significant associations were noted between the highest observed doses of nonsteroidal anti-inflammatory drug (NSAID) exposure and incident kidney problems. The retrospective, longitudinal cohort study used deidentified medical and administrative data on 764,228 active-duty US Army soldiers serving between January 1, 2011, and December 31, 2014. Interventions included mean total defined daily doses of prescribed NSAIDs dispensed per month in the prior 6 months. Researchers found:

  • 65.8% of participants (85.8% men, median age 27.0 years) were not dispensed prescription NSAIDs in the prior 6 months; 17.9% were dispensed 1 to 7 mean total defined daily doses per month, and 16.3% received >7 defined daily doses per month.
  • There were 2,356 acute kidney injury outcomes (0.3%) and 1,634 chronic kidney disease outcomes (0.2%) observed.
  • NSAID prescriptions of >7 daily defined doses per month were associated with modest but significant increases in the adjusted hazard ratios of acute and chronic kidney disease diagnoses.

Citation:

Nelson DA, Marks ES, Deuster PA, O’Connor FG, Kurina LM. Association of nonsteroidal anti-inflammatory drug prescriptions with kidney disease among active young and middle-aged adults. JAMA Netw Open. 2019;2(2):e187896. doi:10.1001/jamanetworkopen.2018.7896.

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